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Unpacking Anxiety and Depression – Could The Mauve Factor be the answer?

The Mauve Factor has also been referred to as ‘Pyroluria’, ‘Kryptopyrroles’ or ‘Pyrrole disorder’. The over production of hydroxyhaempyrrolin (HPL) causes Pyrrole Disorder. Hydroxylactam of hemopyrrole (HPL) is an abnormal side product of porphyrin biosynthetic pathway, which may have a devastating impact on the behavior. Studies have explored measurements of urinary kryptopyrroles and found them to be elevated in individuals with behavioural and emotional disorders such as ADHD, anxiety, depression, schizophrenia, alcoholics, and bipolar disorder.

Pyroluria can be genetic, or induced by oxidative stress, and the presence of kryptopyrroles in the urine usually correlates with nutrient deficiency and leaky gut. Kryptopyrroles bind irreversibly to vitamin B6 (pyridoxine) and zinc, rendering them inactive and depleting them from the body through urinary excretion. A deficiency of arachidonic acid (an omega-6 fatty acid) is also common in pyroluria. Therefore the nutrient deficiencies of Omega 6 fatty acids, B6 and zinc are not available for the body to use in neurotransmitter production and enzyme production leading to dysfunction in the body expressed by behavioural and emotional disorders.

What are the common health issues of The Mauve Factor


Sensitivities to...


Odours (smell)


Texture ( of food clothing etc e.g. Tags on clothes, wool, warm or cold food...)


  • Irritability, moodiness, anger outbursts
  • Sever temper, short fuse sometimes violent
  • Slow to calm down but remorseful later
  • Depression
  • Anxiety
  • Above mood disorders triggered by stressful events and growth spurts
  • Inability to tolerate stress
  • Insomnia/ a night person
  • Poor dream recall or recall of vivid/bizarre dreams only
  • Poor morning appetite nausea, tendency to skip breakfast
  • Poor and deteriorating short term memory
  • Sensitivity to tags on clothes and textures of clothes e.g. wool
  • Sensitivities to textures of food and smells
  • Kids may tend to be picky eaters
  • Adults may tend to prefer spicy and flavoursome foods
  • Prominent morning sickness in pregnancy
  • Reading disorder/dyslexia/poor school performance if onset early
  • Behavioural disorders in children
  • Delayed puberty with growing pains if onset in childhood
  • Fascination with disaster
  • Unstable blood sugar/carbohydrate cravings
  • Sharp stabbing abdominal pains/stitches
  • Tendency for motion sickness

Physical Features

  • Premature grey or balding in men
  • Dry Skin
  • Stretch Marks
  • Acne
  • Short stature if onset in childhood
  • Fair Hair/Skin
  • Inability to tan/easy sunburn/look paler than siblings
  • China Doll Appearance
  • Poor wound healing
  • Recurrent Infections
  • White spots on fingernails, brittle weak nails
  • Cold hands and feet
  • Abdominal tenderness
  • Coarse Eyebrows
  • Tremor

Associated Conditions

  • Depression
  • Anxiety
  • Behavioural Disorders
  • Bipolar Disorder
  • Schizophrenia
  • Autism
  • Alcoholism
  • Downs Syndrome
  • Anorexia
  • Obesity

So what is the role of Zinc and B6?

There are hundreds of processes in the body that rely on Zinc as an essential nutrient to work. Zinc is particularly important for healing, immune function, digestion, neurotransmitter activation, physical growth, memory, insulin sensitivity and control of blood sugars, DNA replication and many others. To produce Neurotransmitters such as serotonin (our happy hormone), melatonin (our sleep hormone), GABA (our relaxation hormone – our natural Valium), and acetyl choline which is important for our memory, we need Zinc and Vitamin B6.

Zinc and Vitamin B6 are also involved in the production of our steroid hormone such as cortisol, and the conversion of oils in the body. The oils EPA/DHA and GLA are often found to be low in those with pyrrole disorder and these oils are damaged by oxidative stress.

How can I test for Pyroluria?

A simple test can be performed to test for The Mauve Factor at a low cost. If you require further information please email

Further resources

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